The Mateus House Foundation is a cultural institution in Vila Real, Portugal, located in the historic Mateus House, an 18th-century Baroque mansion. The foundation is dedicated to promoting culture, education, arts, and sciences. It houses a notable library, an art collection, and hosts cultural events such as concerts, exhibitions, and conferences. Additionally, Mateus House is renowned for its Port wine and has a literary connection to Eça de Queirós' work "The Mateus House." The foundation plays a vital role in preserving and promoting the cultural heritage of the region, making it a significant tourist destination in the Douro region.